Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn.

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dc.contributor.authorNandedkar, T D
dc.contributor.authorSagvekar, P
dc.contributor.authorThakur, B
dc.contributor.authorNavlakhe, R
dc.contributor.authorChitnis, S
dc.contributor.authorMahale, S D
dc.contributor.authorD’Souza, S
dc.contributor.authorPatel, K D
dc.contributor.authorVavia, P R
dc.date.accessioned2014-04-28T10:19:54Z
dc.date.available2014-04-28T10:19:54Z
dc.date.issued2013-11
dc.description.abstractyielded an average particle size of 120 nm with 70% encapsulation-efficiency. In vitro release profile of NP-OP showed sustained release of OP for 21 days. In vivo anti-fertility studies were conducted in marmosets. Results indicated that control animals conceived in the same cycle while two of three treated animals failed to conceive in treatment cycle. The in vivo studies thus corroborate with in vitro release of OP, demonstrating its anti-fertility activity in 66% of animals.en_US
dc.identifier.citationNandedkar T D, Sagvekar P, Thakur B, Navlakhe R, Chitnis S, Mahale S D, D’Souza S, Patel K D, Vavia P R. Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn. Indian Journal of Experimental Biology. 2013 Dec; 51(12): 1055-1062.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150292
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/24553en_US
dc.subjectAnti-fertilityen_US
dc.subjectEncapsulation efficiencyen_US
dc.subjectFollicle stimulating hormone binding-inhibitoren_US
dc.subjectPolylactideen_US
dc.subjectSynthetic peptidesen_US
dc.subjectTEMen_US
dc.subject.meshAnimals
dc.subject.meshCallithrix --physiology
dc.subject.meshCarrier Proteins --administration & dosage
dc.subject.meshCarrier Proteins --chemistry
dc.subject.meshContraception
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshNanoparticles --administration & dosage
dc.subject.meshNanoparticles --chemistry
dc.subject.meshOvarian Follicle --chemistry
dc.subject.meshParticle Size
dc.subject.meshPeptide Fragments --administration & dosage
dc.subject.meshPeptide Fragments --chemistry
dc.subject.meshPolymers --administration & dosage
dc.subject.meshPolymers --chemistry
dc.titlePolymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn.en_US
dc.typeArticleen_US
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