Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma: A literature review.
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Date
2013-04
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Abstract
Cholangiocarcinoma (CCa) is relatively resistant to chemotherapy as well as radiation therapy, and complete resection
is the main curative therapy for these patients. The prognosis for patients with unresectable intrahepatic CCa (iCCa) is
extremely poor. A 55‑year‑old woman presented at our hospital with abdominal pain. After evaluation, she was diagnosed
to have multifocal iCCa. She did not opt for standard chemotherapy and therefore received oral metronomic therapy with
a combination of celecoxib, etoposide, and cyclophosphamide for a total of 30 months. Presently, she is 57 months post
diagnosis and 27 months post cessation of all treatment and continues to be in complete radiological remission. In the
present report, we review the literature and discuss whether metronomic scheduling of biologic agents and anticancer
drugs will be able to overcome chemoresistance and improve the outcome in cholangiocarcinoma. References for the
review were identified through searches of Pubmed for the last 10 years as well as searches of the files of the authors
themselves. The final list was generated on the basis of originality and relevance to this review.
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Keywords
Celecoxib, cholangiocarcinoma, metronomic therapies, oral cyclophosphamide, oral etoposide
Citation
Banavali S D, Patil N R, Nirabhawane V S, Bhosale B B, Desai S B. Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma: A literature review. Indian Journal of Cancer. 2013 Apr-June; 50(2): 149-153.