Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma: A literature review.

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dc.contributor.authorBanavali, S D
dc.contributor.authorPatil, N R
dc.contributor.authorNirabhawane, V S
dc.contributor.authorBhosale, B B
dc.contributor.authorDesai, S B
dc.date.accessioned2013-10-04T08:40:08Z
dc.date.available2013-10-04T08:40:08Z
dc.date.issued2013-04
dc.description.abstractCholangiocarcinoma (CCa) is relatively resistant to chemotherapy as well as radiation therapy, and complete resection is the main curative therapy for these patients. The prognosis for patients with unresectable intrahepatic CCa (iCCa) is extremely poor. A 55‑year‑old woman presented at our hospital with abdominal pain. After evaluation, she was diagnosed to have multifocal iCCa. She did not opt for standard chemotherapy and therefore received oral metronomic therapy with a combination of celecoxib, etoposide, and cyclophosphamide for a total of 30 months. Presently, she is 57 months post diagnosis and 27 months post cessation of all treatment and continues to be in complete radiological remission. In the present report, we review the literature and discuss whether metronomic scheduling of biologic agents and anticancer drugs will be able to overcome chemoresistance and improve the outcome in cholangiocarcinoma. References for the review were identified through searches of Pubmed for the last 10 years as well as searches of the files of the authors themselves. The final list was generated on the basis of originality and relevance to this review.en_US
dc.identifier.citationBanavali S D, Patil N R, Nirabhawane V S, Bhosale B B, Desai S B. Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma: A literature review. Indian Journal of Cancer. 2013 Apr-June; 50(2): 149-153.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148640
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=2;spage=149;epage=153;aulast=Banavalien_US
dc.subjectCelecoxiben_US
dc.subjectcholangiocarcinomaen_US
dc.subjectmetronomic therapiesen_US
dc.subjectoral cyclophosphamideen_US
dc.subjectoral etoposideen_US
dc.subject.meshAdministration, Metronomic
dc.subject.meshCholangiocarcinoma --drug therapy
dc.subject.meshCholangiocarcinoma --pathology
dc.subject.meshCyclophosphamide --administration & dosage
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshPrognosis
dc.subject.meshTumor Microenvironment
dc.titleCan combination metronomic therapy overcome chemoresistance in cholangiocarcinoma: A literature review.en_US
dc.typeArticleen_US
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