Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats.
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Date
2013-03
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Abstract
The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.
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Keywords
Acute pancreatitis, Anti-inflammatory, Cytokines, L-arginine, Lawsone
Citation
Biradar Sandeep, Veeresh B. Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats. Indian Journal of Experimental Biology. 2013 Mar; 51(3): 256-261.