Neuroprotective potential of ethanolic extract of Pseudarthria viscida (L) Wight and Arn against -amyloid(25-35)-induced amnesia in mice.
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Date
2011-06
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Abstract
The neuroprotective potential of ethanolic extract of roots of Pseudarthria viscida (L) Wight and Arn (EEPV) was investigated against -amyloid(25-35)-induced amnesia in mice which is a suitable animal model for Alzheimer’s disease (AD). The senile plaques of -amyloid (A) are major constituents accumulated during the progression of AD as a potent neurotoxicant. In our investigation, intracerebroventricular injection of A(25-35) in mice induced the neurodegeneration, exhibited the increased time of escape latency in behavioral pattern using water maze and decreased the levels of antioxidants namley superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and vitamin C with elevated level of acetylcholinesterase enzyme (AChE). The neuroprotective potential of EEPV was determined by behavioral pattern using water maze and biochemical parameters such as SOD, CAT and GPx and vitamin C content as well as AChE. Mice were treated with EEPV at 200 and 400 mg/kg doses for 21 days. Except control, all animals received a single injection of neurotoxicant A(25-35) on 14th day. In behavioural assessment, treatment with ethanolic extract improved the cognitive function in the water maze and attenuated the elevated levels of AChE with increase in antioxidant enzymes, indicating the neuroprotection with increased levels of vitamin C. These findings suggest that ethanolic extract of P. viscida exerts anti-amnesiac effects and enhances cognitive function.
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Keywords
Alzheimer’s disease, -Amyloid, Acetylcho-linesterase, Water maze, Oxidative stress, Pseudarthria viscida (L) Wight and Arn, Antioxidant enzymes, Vitamin C
Citation
Singh J C Hanish, Alagarsamy V, Parthiban P, Selvakumar P, Reddy Y Narsimha. Neuroprotective potential of ethanolic extract of Pseudarthria viscida (L) Wight and Arn against -amyloid(25-35)-induced amnesia in mice. Indian Journal of Biochemistry & Biophysics. 2011 June; 48(3): 197-201.