Emerging Molecular Targets for the Treatment of Asthma.
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Date
2009-12
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Abstract
Current therapeutic approaches for the treatment of asthma have limitations in their ability to target all the features of the disease. Indeed, existing pharmacological asthma therapies are based on decades old strategies that were developed prior to the rapid growth in knowledge stemming from cell and molecular biology in the past decade. Thus, there is an unmet need for developing new drugs to target these features along with improved efficacy and safety. In the present review, the limitations of prevalent pharmacological asthma therapy are discussed briefly, and some explanations are suggested as to why new therapeutic targets are required to treat asthma, and finally directions for novel asthma therapies are proposed.
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Keywords
Asthma, Airway hyperresponsiveness, Inflammation, Airway remodeling, PDE4 inhibitors, Statins, Rho kinase, Cytokines, Bronchodilators, PI-3 kinase inhibitors, Antisense oligonucleotides, Transcription factors, Kinase inhibitors, CpG oligonucleotides, H4 receptors
Citation
Sharma Pawan, Halayko Andrew J. Emerging Molecular Targets for the Treatment of Asthma. Indian Journal of Biochemistry & Biophysics. 2009 Dec; 46(6): 447-460.