Prevalence of TEL/AML1 fusion gene in Thai children with B-cell precursor ALL using FISH technique
No Thumbnail Available
Date
2010-12-21
Journal Title
Journal ISSN
Volume Title
Publisher
Khon Kaen University
Abstract
The prevalence of TEL/AML1 fusion (translocation ets leukemia/ acute myeloid leukemia 1) in Thai children with B-cell precursor acute lymphoblastic leukemia (ALL), fluorescence in situ hybridization (FISH) was determined in 31 patients. TEL/AML1 translocation was detected in 10 patients (32.3 %). Other co-existing aberrations with TEL/AML1 were found including multiple copies of AML1 gene in 2 patients (6.4 %), TEL gene deletion in 5 patients (16.1 %). TEL gene deletion was observed in association with extra copies of AML1 in 1 case (3.2 %). DNA probe specific FISH revealed as a high-performance tool to exhibit TEL/ AML1 fusion in B-cell precursor childhood ALL patients. With high incidence of TEL/ AML1 fusion translocation detected by FISH in this study, further areas of chromosome alterations may be revealed using FISH technique. This should be beneficial in diagnostics and planning of treatment for the ALL patients.
Description
Keywords
Citation
Journal of Medical Technology and Physical Therapy; Volume 22 Number 3, September - December 2010; 230-239