A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia.

Feit, Ira N; Pawlikowski, Jeffrey; Zawilski, Caroline

A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia.

Date

2007-03-17

Authors

Feit, Ira N

Pawlikowski, Jeffrey

Zawilski, Caroline

Abstract

The three basic cell types in the migrating slug of Dictyostelium discoideum show differential chemotactic response to cyclic AMP (cAMP) and differential sensitivity to suppression of the chemotaxis by ammonia.The values of these parameters indicate a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types.We present a model that explains the localization of the three cell types within the slug based on these chemotactic differences and on the maturation of their chemotactic properties.

Citation

Feit IN, Pawlikowski J, Zawilski C. A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia. Journal of Biosciences. 2007 Mar; 32(2): 329-38