National Medical Journal of India
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Item Post-angiographic femoral artery injuries.(1992-01-01) Buckley, J GItem The trade in human organs.(1992-01-01) Mani, M KItem The right to die.(1992-01-01) Silva, Y JItem Maurice King replies.(1992-01-01)Item Postictal hyperprolactinaemia.(1992-01-01) Tharyan, PItem Changing convictions with changing journals?(1992-01-01) Kulkarni, VItem Immunization against typhoid fever.(1992-01-01) Balraj, V; Sridharan, G; Jesudason, M V; Balaraj, VItem Left ventricular mass and geometry in essential hypertension.(1992-01-01) Misra, A; Jain, PItem Gastric cancer and surgical workload.(1992-01-01) Kohli, H SItem Cyclophosphamide cardiotoxicity.(1992-01-01) Kumar, S; Gupta, R K; Samal, NItem More on "human entrapment ...'.(1992-01-01) Antia, N HItem Ethical concerns in AIDS, a national workshop organized by the FIAMC Bio-medical Ethics Centre, Bombay, 27-28 April 1991.(1992-01-01) Vas, C J; De Souza, E JItem Patient service or patient care?(1992-01-01) Cariappa, AItem Doctors on strike.(1992-01-01) Pandya, S KItem HLA and complement C4 studies in psoriasis vulgaris.(1992-01-01) Chablani, U A; Contractor, N M; Gadgil, R BBACKGROUND. Psoriasis vulgaris is known to be associated with the presence of certain HLA antigens and complement factors but only studies of Western populations have been reported. We investigated the HLA and complement profile in Indian patients with psoriasis vulgaris. METHODS. Sixty-seven patients and 132 normal subjects were typed for class I antigens using 262 sera, and 55 patients and 104 normal subjects were typed for class II antigens using 174 sera. The sera from patients and normals were sent to Japanese laboratories for the study of class III antigens. RESULTS. The study revealed that patients had an increased frequency of A1 (p < 0.0025), B17 (p < 0.0025), Cw6 (p < 0.001) DR7 (p < 0.05) and DQw3 (p < 0.005) when compared to normal controls. Analysis of two and three antigen haplotypes revealed a significant increase in the incidence of all haplotypes involving those antigens which showed a high frequency among patients. A significant association was also found with complement factors C4A6.3 and C4A6,X. However, the relative risk was high for C4BQO (10.73). CONCLUSIONS. Psoriasis in Indians is associated with the A1, B17 and Cw6 but not with B13 antigens and the complement allotypes mentioned above. The strong association with C4 factors may be as a result of a close linkage between the class III region and Ir genes.Item Detection of hepatitis B virus DNA in donor blood by the polymerase chain reaction.(1992-01-01) Nandi, J; Banerjee, KBACKGROUND. Blood collected from voluntary donors at local blood banks and blood donation camps was screened for the hepatitis B virus genome using the polymerase chain reaction and for viral markers by standard serological techniques. The sensitivities of the two screening strategies were compared. METHODS. One hundred and twenty-six blood samples were tested for HBV serological markers--HBsAg, anti-Hbs and anti-HBc--by ELISA. The same samples were also subjected to the polymerase chain reaction using primers made by us. RESULTS. Analysis of the polymerase chain reaction amplified products revealed that 24% of the blood samples which tested negative for HBsAg using the ELISA technique were positive for HBV DNA by the polymerase chain reaction. All the HBsAg positive samples (by ELISA) were also positive by the polymerase chain reaction (which detected additional samples as well). Anti-HBc antibodies showed a much greater concordance with the polymerase chain reaction. CONCLUSIONS. The results emphasize that the screening strategies for donor blood need to be re-evaluated in order to check inadvertent transmission of hepatitis B virus during blood transfusion. The ELISA technique to detect HBsAg as the sole serological marker is inadequate to indicate the actual prevalence of hepatitis B virus in the donor blood. The polymerase chain reaction may be a better screening test. If this is not available, the detection of anti-HBc antibodies appear to be a better means of screening blood than HBsAg.Item National Medical Library.(1992-01-01) Srivastava, S KItem Management of intrauterine foetal death.(1992-01-01) Dhall, K; Kaur, JItem More on 'human entrapment ...'.(1992-01-01) Soman, C R; Vijayakumar, K