Roy, ASoni, G RKolhapure, R MBanerjee, KPatki, P S2009-05-282009-05-281992-08-01Roy A, Soni GR, Kolhapure RM, Banerjee K, Patki PS. Induction of tumour necrosis factor alpha in experimental animals treated with hepatotoxicants. Indian Journal of Experimental Biology. 1992 Aug; 30(8): 696-700http://imsear.searo.who.int/handle/123456789/56624Administrations of hepatotoxicants namely carbon tetrachloride (CCl4:0.4 ml in 1.2 ml of liquid paraffin) and ANIT (1 ml of 1.5% solution in liquid paraffin) in Charles foster rats (force fed) and D-galactosamine (8 mg in water per swiss albino mouse, ip) induce the release of TNF-alpha in case of CCl4 and D-galactosamine. High TNF-alpha level was observed up to 48 hr in CCl4 and up to 24 hr in D-galactosamine treated animals. Elevated levels of biochemical like ALP and SGPT are also recorded. TNF-alpha level can be measured of tissue damage and prognosis in case of hepatitis.eng1-Naphthylisothiocyanate --pharmacologyAlanine Transaminase --bloodAlkaline Phosphatase --bloodAnimalsCarbon Tetrachloride --pharmacologyGalactosamine --pharmacologyLiver --drug effectsMiceRatsTumor Necrosis Factor-alpha --biosynthesisJournal Article