SreedharanKalpana, DevadathanPA, Mohammed KunjuBindusha, SasidharanJayakumar, Parameswaran PillaiMinikumari, Amma Vasumathy AmmaSaboorabeegum, MuthuBeevi2020-04-232020-04-232018-04Sreedharan, Kalpana Devadathan, PA Mohammed Kunju, Bindusha Sasidharan, Jayakumar Parameswaran Pillai, Minikumari Amma Vasumathy Amma, Saboorabeegum MuthuBeevi. Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. Indian Pediatrics. 2018 Apr; 55(4): 307-3100974-75590019-6061http://imsear.searo.who.int/handle/123456789/199063Objective: To assess the effect of monotherapy withCarbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH vitamin D levels in children with epilepsy compared tocontrols.Design: Cross-sectional study.Setting: Outpatient department of a tertiary-care PediatricNeurology centre, and a nearby day-care centre and school.Study period: June 2012 to May 2013Participants: Children with epilepsy aged 2 to 13 years onmonotherapy with CBZ (n=28) or VPA (n=28) for at least 6months; 109 age-matched controls from a nearby day-care centreand school.Results: The median (IQR) values of 25 (OH) vitamin D was 18.0ng/mL (13.7-27.3), 21.35 ng/mL (16.4 -25.2) and 30.5 ng/mL(19.1-43.7) in CBZ, VPA and control group, respectively (P=0.008). 60.7% of patients in CBZ group and 35.7 % in VPA grouphad low 25 (OH) D levels (<20 ng/mL) compared to 27.8% incontrols (P=0.001).The serum alkaline phosphatase level washigher in children on carbamazepine therapy (P=0.001) thancontrols.Conclusion: This study identifies significant risk of vitamin Ddeficiency in ambulant children with epilepsy on monotherapy withCBZ or VPA.Adverse effect; Antiepileptic drugs; Hypovitaminosis DJournal ArticleIndiaDepartments of Pediatric Neurology, Medical College, Thiruvananthapuram, India.Pediatrics, Medical College, Thiruvananthapuram, India.Biochemistry; Government Medical College, Thiruvananthapuram, India.