Prajapati, Anuradha P.Patel, Pratik S.Vadgama, Neha S.Narkhede, SachinLuhar, ShaileshGandhi, Shivani J.2024-09-242024-09-242024-09-242024-09-242023-06Prajapati Anuradha P., Patel Pratik S., Vadgama Neha S., Narkhede Sachin, Luhar Shailesh, Gandhi Shivani J. . FORMULATION DEVELOPMENT AND EVALUATION OF SOLID SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF AZELNIDIPINE . International Journal of Pharmaceutical Sciences and Drug Research . 2023 May; 15(3): 237-2490975–248Xhttps://imsear.searo.who.int/handle/123456789/231674This study aimed to develop a self-micro emulsifying drug delivery system (SMEDDS) for poorly soluble azelnidipine using Capryol 90 as the oil, Tween 80 as the surfactant, and transcutol-HP as the co-surfactant. A factorial design was used to optimize the formulation, and Neusilin UFL2 was used as an adsorbent to convert the liquid SMEDDS to solid SMEDDS. The optimized formulation had a particle size of 80.5nm, a transmittance of 98.2%, a zeta potential of -3.1 mV, and a polydispersibility index of 0.226. The solid SMEDDS tablet exhibited improved drug release (99.4% in 60 minutes) compared to the marketed tablet (67.09.75%) and pure drug (26.17%). This study demonstrates the potential of the SMEDDS approach to enhance the solubility and in-vitro drug release of poorly soluble drugs such as azelnidipine.Self-emulsifying drug delivery systemsAzelnidipine poorly solublePseudo-ternary phase diagramJournal ArticleIndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, IndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, IndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, IndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, IndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, IndiaDepartment of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Vapi, Gujarat, India