Nemade, SHKamal, MM.2023-08-102023-08-102023-03Nemade SH, Kamal MM.. Body fluids: Comparison of liquid based cytology with conventional cytopreparatory technique. Indian Journal of Pathology & Microbiology. 2023 Mar; 66(1): 75-800377-49290974-5130http://imsear.searo.who.int/handle/123456789/223389Introduction: In the diagnosis of malignant tumors, cytological examinations of various body fluids are useful. For the preparation of body fluid, many methods are used till date. The use of liquid-based cytology is new upcoming in the field. Aim: To examine the performance of liquid-based cytology on body cavity fluids as compared to conventional cytopreparatory techniques. Methodology: In the present study, 700 body fluid samples were processed by both liquid- based cytology (BD SurePath™) and conventional cytopreparatory technique (Thick & Thin). The performance of both techniques was compared in terms of “smear quality” and “overall diagnostic test performance.” Results: Out of 155 body fluid samples from proven malignancy patients, 32 (20.65%) were reported as Positive for malignancy, 23 (14.84%) as Suspicious of malignancy, and 100 (64.51%) as Negative for malignancy by CS (Thick and Thin). A total of 44 (28.39%) were reported as Positive for malignancy, 12 (7.74%) as Suspicious of malignancy, and 99 (63.87%) as Negative for malignancy by LBC. Conclusion: Liquid-based cytology is advantageous over conventional techniques in cytomorphology of body fluids, but not better in sensitivity and specificity. Also saves cytopathologist's valuable time for screening.Cytomorphology, cytopathology, liquid-based cytologyJournal ArticleIndiaDepartment of Pathology, Government Medical College, Nagpur; Dr. Nemade Nidan Pathology Laboratory and Research Center, Akot, Maharashtra, IndiaDepartment of Pathology, Government Medical College, Nagpur, Maharashtra, India