Flores, Sergio V.OLIVARI, Carla F.PRADO, Luis Flores2020-11-182020-11-182020-01Flores Sergio V., Olivari Carla F., Prado Luis Flores. Signatures of positive selection on the hepatic lipase gene in human populations. Journal of Genetics. 2020 Jan; 99: 1-50022-13330973-7731http://imsear.searo.who.int/handle/123456789/215564The hepatic lipase plays a central role in the lipid metabolism, catalyzing the hydrolysis of phospholipids, monoglycerides, diglycerides, and triglycerides, and acyl-CoA. It is also implied in the conversion of very low-density lipoprotein and intermediate density lipoprotein to low density lipoproteins. As a consequence, the gene encoding the hepatic lipase (LIPC) is associated with several diseases derived from the imbalance of lipids that are in general derived from the interaction between life styles and genetic architecture. Therefore, it is interesting to understand more about the characteristics of the microevolutionary processes affecting genes that, like LIPC, have a role in nutrition and lipid metabolism in human populations. We explored the selection signatures on LIPC in 26 populations, detecting three regions under recent positive selectionhepatic lipasepositive selectionTajima’s DFu and Li test1000 genomes.Journal ArticleIndiaLaboratorio de Gene´tica y Bioantropologı´a, Departamento de Antropologı´a, Facultad de Ciencias Sociales, Universidad de Chile, Avenida Ignacio Carrera Pinto 1045, N˜ un˜oa 7750000, Santiago, ChilePresent Address: Labortorio de Geno´mica Evolutiva, N˜ un˜oa 7750000, Santiago, ChileLaboratorio de Gene´tica y Bioantropologı´a, Departamento de Antropologı´a, Facultad de Ciencias Sociales, Universidad de Chile, Avenida Ignacio Carrera Pinto 1045, N˜ un˜oa 7750000, Santiago, ChileInstituto de Entomologı´a, Universidad Metropolitana de Ciencias de la Educacio´n, N˜ un˜oa 7750000, Santiago, Chile