Areekul, SuvitCheeramakara, Cheeraratana2012-05-142012-05-141987-04Areekul Suvit, Cheeramakara Cheeraratana. Cholinesterase and acetylcholineslinesterase activities in mice infected with plasmodium berghei. Siriraj Medical Journal, 1987 Apr; 39(4): 185-189.http://imsear.searo.who.int/handle/123456789/138363Cholinesterase (ChE) and acetylcholinesterase (AChE) activities were measured in serum, red cells, liver and spleen of normal and P. berghei – infected mice. Both serum ChE and red cell AChE activities in the infected group were found to be significantly higher than those of normal group. As only a negligible AChE activity was detected in the isolated P. berghei parasites and the parasitaemia showed no relationship to the erythrocyte AChE activity, this indicated that P. berghei possessed no AChE activity. The infected liver was significantly enlarged and contained elevated AChE and slightly but not significantly increased ChE and protein contents. The spleen was increased about 3 folds by weight which resulted in the slightly elevated ChE and AChE contents in the spleen of the infected mice. The elevated serum ChE and red cell AChE activities were therefore possibly due to the compensatory mechanism of the hepato-splenomegaly by having accelerated extramedullary erythropoiesis in the spleen and increased synthesis of ChE by the liver in mice infected with P. berghei.enCholinesteraseAcetylcholineslinesterase activitiesPlasmodium bergheiArticle