Padmaja, SRaju, T N2005-01-112009-06-012005-01-112009-06-012005-01-11Padmaja S, Raju TN. Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. Indian Journal of Physiology and Pharmacology. 2005 Jan; 49(1): 111-4http://imsear.searo.who.int/handle/123456789/107285Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.engAdministration, OralAnimalsAntioxidants --administration & dosageCurcumin --administration & dosageEnzyme Inhibitors --administration & dosageL-Lactate Dehydrogenase --antagonists & inhibitorsLiver --drug effectsMalate Dehydrogenase --antagonists & inhibitorsMaleRatsRats, WistarSelenium --toxicitySuccinate Dehydrogenase --antagonists & inhibitorsComparative Study