Rahman, SharminMasum, Md. Abdullah AlSharmin, FloridaIslam, S M AshrafulReza, Md. Selim2014-05-242014-05-242012-06Rahman Sharmin, Masum Md Abdullah Al, Sharmin Florida, Islam S M Ashraful, Reza Md Selim. Formulation and Evaluation of Bi-layered Sustained Release Matrix Tablets of Tramadol Hydrochloride. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 129-134.http://imsear.searo.who.int/handle/123456789/151268Bi-layer tablets of tramadol hydrochloride were prepared by direct compression technique incorporating an immediate release layer and a sustained release layer. An immediate release layer was successfully designed to release the bolus dose instantaneously. Water soluble Xanthan gum, water insoluble Kollidon SR and Eudragit L 100 were used as carriers in the sustained release layer of the matrix tablet. All the tablets were evaluated for thickness, diameter, weight variation, hardness and friability. The in vitro drug release was studied for eight hour, first two hours dissolution in acidic medium followed by six hour dissolution in buffer medium. Matrix tablet showed a sustained release rate with a controlled fashion as a function of the quantity of polymer used. The in vitro drug release data were fitted with several mathematical models and mean dissolution time along with fractional dissolution time values (T25%, T50% and T80%) were calculated. Xanthan gum was found to be the most effective rate retarding agent compared to Kollidon SR and Eudragit L 100, when used at same ratio in the formulations.enBi-layer tabletMatrix tabletimmediate release layersustained release layerrelease exponents and MDTArticle