Samaddar, ATalukdar, MPal, SSaha, IChowdhury, AR.2023-06-272023-06-272022-05Samaddar A, Talukdar M, Pal S, Saha I, Chowdhury AR.. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. National Journal of Physiology, Pharmacy and Pharmacology. 2022 May; 12(5): 639-6422231-32062320-4672http://imsear.searo.who.int/handle/123456789/217554Background: Although most of the COVID-19 patients presented with mild symptoms and recovered, a considerable number of cases became serious with poor prognosis in an unpredictable manner. They mostly presented with respiratory symptoms and coagulation abnormalities with thrombosis and multi-organ failure. Hence, timely prediction of these cases with the early intervention might decrease mortality. Aims and Objectives: The objectives of this were to determine whether values of fibrinogen, fibrin degradation products (FDP), and D-dimer level correlates with disease severity in COVID-19 patients. Materials and Methods: This observational cross-sectional study was done on total 400 hospitalized COVID-19 adult patients where patients were categorized into moderate and severe cases as per guideline of Government of India. Patients with pre-existing coagulation disorder or receiving anticoagulant drugs were excluded from the study. FDP, fibrinogen, and D-dimer values of these two groups were evaluated and compared statistically to determine their significance. Results: Overall mean and standard deviation of fibrinogen, FDP, and D-dimer were 607.48 ± 177.73, 34.93 ± 29.2, and 6.23 ± 6.48 for severe category, while for moderate category disease, they were 389.77 ± 110.16, 10.79 ± 10.47, and 1.96 ± 3.3, respectively. Unpaired t-test showed that the study parameters are significantly higher in severe COVID-19 patients compared to moderate ones. Conclusion: It was concluded that elevated level of D-dimer, fibrinogen, and FDP is indicator of disease progression in COVID-19. Thus, regular estimation of these simple coagulation parameters may predict disease severity and help in adequate management.COVID-19FibrinogenFibrin Fibrinogen degradation productsD-dimerSeverityJournal ArticleIndiaDepartment of Pathology, Medical College and Hospital, Kolkata, West Bengal, IndiaDepartment of Biochemistry, Medical College and Hospital, Kolkata, West Bengal, IndiaDepartment of Pathology, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India