Lall, S BDas, NRama, RPeshin, S SKhattar, SGulati, KSeth, S D2009-05-282009-05-281997-02-01Lall SB, Das N, Rama R, Peshin SS, Khattar S, Gulati K, Seth SD. Cadmium induced nephrotoxicity in rats. Indian Journal of Experimental Biology. 1997 Feb; 35(2): 151-4http://imsear.searo.who.int/handle/123456789/61516Onset of hypertension and nephropathy after 1,2, and 4 weeks of exposure to cadmium chloride (1 mg/kg, ip) was studied in rats by measuring changes in blood pressure and renal function (urinary output, electrolytes, serum creatinine, inulin clearance and Na+K+ ATPase). Significant decrease in body weight and rise in blood pressure were observed as early as one week of exposure while microalbuminuria was detected in 50% of the animals after 2 weeks. Na+K+ ATPase, a renal tubular enzyme, was depressed after 1 week with maximum lowering occurring after 4 weeks. There were no detectable changes in fluid intake, urine output, electrolytes, inulin clearance and serum creatinine even after 4 weeks. It is concluded that hypertension and tubular lesion set in earlier than glomerulopathy as indicated by microalbuminuria and the latter could be the consequence of rise in blood pressure.engAnimalsBlood Pressure --drug effectsCadmium --toxicityInulin --urineKidney --drug effectsMalePotassium --urineRatsSodium --urineSodium-Potassium-Exchanging ATPase --metabolismJournal Article