Anilakumar, K RKhanum, FarhathSudarshanakrishna, K RSanthanam, K2009-05-282009-05-282004-06-21Anilakumar KR, Khanum F, Sudarshanakrishna KR, Santhanam K. Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver. Indian Journal of Experimental Biology. 2004 Jun; 42(6): 595-600http://imsear.searo.who.int/handle/123456789/59000Effect of prefeeding dehydrated amaranth (A. gangeticus) leaves at 10 and 20% levels on a chemical toxicant, dimethylhydrazine (DMH)-induced free radical stress in rat liver was evaluated. DMH-induced rise in hepatic malondialdehyde (MDA), was diminished by AL. AL intake resulted in a significant increase in hepatic glutathione (GSH). The feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity, while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. Amaranth leaves at 10 and 20% levels of feeding diminished the hepatic superoxide dismutase and glutathione peroxidase (GSH-Px) activities. DMH influenced adversely the hepatic antioxidant enzyme activities. Simultaneous administration of DMH and feeding of AL enhanced the DMH-induced decrease in hepatic GSH-Px. DMH enhanced formation of micronuclei was reverted significantly by AL intake. Hence, it was concluded that the consumption of AL at 20% level reduced DMH-induced impaired antioxidant status in rat liver.engAmaranthus --metabolismAnimalsAntioxidants --metabolismBody WeightBone Marrow --metabolismColon --metabolismDimethylhydrazines --pharmacologyFree RadicalsGlucosephosphate Dehydrogenase --metabolismGlutathione --metabolismGlutathione Peroxidase --metabolismGlutathione Reductase --metabolismLipid PeroxidationLiver --enzymologyMaleMalondialdehyde --pharmacologyMicronuclei, Chromosome-Defective --metabolismOrgan SizeOxidative StressPlant Extracts --pharmacologyRatsRats, WistarSuperoxide Dismutase --metabolismJournal Article