Phadte, AdityaSarathi, VijayaBudyal, SwetaLila, AnuragMemon, Saba SamadKarlekar, ManjiriPatil, VirendraShah, NaliniBandgar, Tushar2023-08-252023-08-252023-06Phadte Aditya, Sarathi Vijaya, Budyal Sweta, Lila Anurag, Memon Saba Samad, Karlekar Manjiri, Patil Virendra, Shah Nalini, Bandgar Tushar. Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India. Indian Pediatrics. 2023 Jun; 60(6): 463-4660079-60610974-7559http://imsear.searo.who.int/handle/123456789/225428Objective: To describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children. Methods: Clinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied. Results: Pubertal onset was earlier in boys than girls (29 vs 75 months, respectively; P=0.008). The basal luteinizing hormone (LH) was ?0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH ?5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was ?0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction to long-acting GnRH agonist. Among GnRH agonist-treated girls (n=24), the predicted final adult height was -1.67±1.5 SDS, whereas the attained final height was -0.25±1.48 SDS. Conclusion: We establish the safety and efficacy of long acting GnRH agonist therapy in Indian children with GDPP. The 60-minute stimulated serum LH/FSH of ?0.34 differentiated GDPP from premature thelarche.GnRHa stimulation testManagementPremature thelarchePubarche.Journal ArticleIndiaDepartment of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, MaharashtraDepartment of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, KarnatakaDepartment of Endocrinology, Fortis Hospital, Mumbai, Maharashtra.