Thanakit, VoranuchSampatanukul, PichetRuangvejvorachai, PreechaKeelawat, Somboon2009-05-272009-05-272005-09-21Thanakit V, Sampatanukul P, Ruangvejvorachai P, Keelawat S. The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients. Journal of the Medical Association of Thailand. 2005 Sep; 88 Suppl 4(): S30-5http://imsear.searo.who.int/handle/123456789/43807Chotmaihet Thangphaet.BACKGROUND: Breast carcinoma is one of the most common tumors in female patients, and its metastasis is a major cause of death. An experimental model has recently found the association of CD44 with MMP-9 that facilitates tumor cell invasion and metastasis. MATERIAL AND METHOD: The CD44v4 and MMP-9 were performed on tissue in paraffin blocks of 50 cases of high-grade breast carcinoma with node positive and 50 cases with node negative. RESULTS: Increased expression of MMP-9(60%) significantly observed in high-grade breast carcinoma patients with node positive (p = 0. 004), whereas CD44v4 displays no significant difference between the two groups (p-value = 0.81). Significant co-expression of CD44v4+ / MMP-9+ (46%) was observed and correlated with node-positive patients whereas the CD44v4+ / MMP-9- (54%) express in node-negative patient (p-value = 0.01). CONCLUSION: The solely expression of CD44v4 does not associate with node status. MMP-9 plays an important role to enhance breast carcinoma cell invasion and associates with lymph node metastasis. The combined expression of CD44v4 (overexpression) and derangement of MMP-9 expression was significantly associated with nodal status.engAntigens, CD44 --metabolismBreast Neoplasms --enzymologyCarcinoma --enzymologyFemaleHumansImmunohistochemistryLymph Nodes --enzymologyLymphatic MetastasisMatrix Metalloproteinase 9 --metabolismIn Vitro