Pawar, PDhama, AChahal, AGhalaut, VS.2025-05-142025-05-142024-12Pawar P, Dhama A, Chahal A, Ghalaut VS.. Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Dec; 14(12): 2607-26112231-32062320-4672https://imsear.searo.who.int/handle/123456789/247839Background: Type 2 diabetes mellitus (DM) is rising as a major health concern worldwide. The pathogenesis of DM and its complications involve an array of dynamic interactions between genes, inflammatory cytokines like TNF-?, oxidative stress, environmental factors, and lifestyle. Several studies have shown a strong correlation of Ox-LDL (Ox- idized low-density lipoprotein) and TNF-? (tumor necrosis factor-?) with IR (insulin resistance). Hence, the present study was designed to study the correlation between HbA1c (glycated hemoglobin) (a marker of glycemic control) with TNF-? (a marker of chronic inflammation) and Ox-LDL (a marker of oxidative stress). Aim and objectives: To study the correlation between TNF-? and Ox-LDL with HbA1c in Type 2 DM. Methods: For our pilot study, we recruited patients with type 2 DM belonging to the age group 35-50 years of either gender from Medicine OPD as cases. The institutional ethics committee approval has been taken before commence- ment of the study. After informed consent from patients, venous blood samples were collected and analyzed using a biochemistry autoanalyzer and appropriate ELISA kit. Data were analyzed statistically using SPSS software. Result: The study showed raised levels of HbA1c, TNF-?, and OX-LDL in type 2 DM patients. Conclusion: Furthermore, a significant positive correlation was observed between TNF-? and HbA1c (r = 0.829) and also between Ox-LDL and HbA1c (r = 0.638).type 2 diabetes mellitusglycated haemoglobintumor necrosis factor ?oxidized low density lipoproteinCorrelation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DMJournal ArticleIndiaDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, IndiaDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, IndiaDepartment of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, IndiaDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, India