Jat, Kana RamKumar, PrawinMukherjee, AparnaShivani, RandevBipin, JoseM, KalaivaniLodha, RakeshKabra, Sushil K2020-04-232020-04-232020-03Jat Kana Ram, Kumar Prawin, Mukherjee Aparna, Shivani Randev, Bipin Jose, M Kalaivani, Lodha Rakesh, Kabra Sushil K. Wheezing in Preschool Children and Total IgE Levels: A Birth Cohort Study. Indian Pediatrics. 2020 Mar; 57(3): 235-2380974-75590019-6061http://imsear.searo.who.int/handle/123456789/199504Objectives: To evaluate association between total IgE levels and wheezing in preschoolchildren from India. Methods: Datawere collected in a prospective birth cohort study relatedto wheezing till three years of age. Total IgE was measured at enrolment, at one year and twoyears of age and correlated with wheezing episodes. Results: A total of310 (167 boys)children were enrolled. Total IgE levels increased with age (P<0.001). Overall, 101 (32.6%)children had 182 episodes of wheezing. The median (IQR) total IgE levels in children withwheezing and without wheezing were similar at one year [42.1 (12.7, 93.5) vs 41.9 (17.1,96.7) kU/L; P=0.39] and two years of age [62.8 (32.4, 212.0) vs 75 (25.8, 173.0) kU/L,P=0.92). Conclusion: Total IgE levels increased with age and were not different in preschoolchildren with and without wheezing.Immunoglobin ERhonchiUnder-five wheezerJournal ArticleIndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaBiostatistics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, India