Niture, Netaji TAnsari, Ansar ANaik, Suresh R2014-12-112014-12-112014-07Niture Netaji T, Ansari Ansar A, Naik Suresh R. Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers. Indian Journal of Experimental Biology. 2014 Jul; 52(7): 720-727.http://imsear.searo.who.int/handle/123456789/153752Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition.enAntidiabetic activityAntioxidantsLipid profilePro-inflammatory cytokinesRutinStreptozotocinAnimalsAntioxidants --metabolismBiological Markers --metabolismBlood Glucose --analysisBody Weight --drug effectsDiabetes Complications --drug therapyDiabetes Complications --etiologyDiabetes Complications --metabolismDiabetes Mellitus, Experimental --complicationsDiabetes Mellitus, Experimental --drug therapyDiabetes Mellitus, Experimental --metabolismDiabetes Mellitus, Type 2 --complicationsDiabetes Mellitus, Type 2 --drug therapyDiabetes Mellitus, Type 2 --metabolismDiet, High-Fat --adverse effectsFemaleHemoglobin A, Glycosylated --analysisHyperglycemia --drug therapyHyperglycemia --etiologyHyperglycemia --metabolismHypoglycemic Agents --pharmacologyInsulin --metabolismInsulin-Secreting Cells --metabolismInterleukin-6 --metabolismLipids --bloodMaleMiceRats, Sprague-DawleyRutin --pharmacologyThiazolidinediones --pharmacologyTumor Necrosis Factor-alpha --metabolismArticle