Kim, YASung, WJ2025-06-192025-06-192025-03Kim YA, Sung WJ. The immunohistochemical expression of c-MET and RON in lung adenocarcinoma with clinicopathologic correlation. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 23-290377-49290974-5130https://imsear.searo.who.int/handle/123456789/249957Background: Mesenchymal epidermal transition (MET) and receptor originating from nantes (RON) are transmembrane tyrosine kinase receptors. Both are members of a proto?oncogene family and thus play a role in the pathogenesis of various cancers and acquired resistance to kinase inhibitors in lung cancer. Aims: The aim of this study was to investigate the immunohistochemical expression of c?MET and RON in lung adenocarcinoma and its clinicopathologic correlation. Settings and Design: Retrospective study. Materials and Methods: The immunohistochemical c?MET and RON expression in specimens obtained from lung adenocarcinoma (n = 175) and associated clinicopathologic parameters were evaluated. Statistical Analysis Used: The correlation between c?MET and RON expression was analyzed by Chi?square test. A Cox proportional hazards model and Kaplan?Meier curve analysis were used to evaluate the risk factors and prognosis. Results: High expression of the c?MET protein showed a strong correlation with that of RON (P = 0.013, kappa = 0.183). Five?year survival and recurrence?free 5?year survival were not associated with high expression of c?MET or RON. High c?MET expression was significantly associated with age older than 60 years (P = 0.000), tumor differentiation (P = 0.009), lymphovascular invasion (P = 0.016), and pleural invasion (P = 0.005). High RON expression was associated with a solid growth pattern (P = 0.001) and pleural invasion (P = 0.002). Conclusions: The results point to the potential of immunohistochemical expression of c?MET and RON as useful prognostic markers of unfavorable histopathologic features in lung adenocarcinoma.c?METlung adenocarcinomanon?small cell lung cancerRONJournal ArticleIndiaDepartment of Pathology, Daegu Catholic University School of Medicine, Duryugongwon?ro 17?gil 33, Nam?gu, Daegu 42472; Seoul Clinical Laboratories of Daegu, 95, Hwarang?ro, Dong?gu, Daegu, 41238, Republic of KoreaDepartment of Pathology, Daegu Catholic University School of Medicine, Duryugongwon?ro 17?gil 33, Nam?gu, Daegu 42472