Kumar, DhanajayArora, K.K.Jain, Parul2020-09-242020-09-242019-04Kumar Dhanajay, Arora K.K., Jain Parul. To Evaluate the Effectiveness of Magnesium Sulphate as an Agent to induce Hypotensive Anaesthesia in Lumbar Spine Surgery. A Prospective Randomized, Placebo-Control Study. International Journal of Contemporary Medical Research . 2019 Apr; 6(4): d4-d72393-915X2454-7379http://imsear.searo.who.int/handle/123456789/202316Introduction: This randomized placebo controlled study wasdesigned to evaluate the effectiveness of magnesium sulphateas an agent to induce hypotensive anaesthesia in lumbar spinesurgery.Material and Methods: The study included 100 patients ofboth sexes who were equally distributed in two groups, theGroup Mg(Magnesium sulphate group) and Group C (controlgroup). The Magnesium group received magnesium sulphate40mg/kg administered as a slow IV bolus over a period of 10minutes before induction and 15mg/kg/hr by continuous IVinfusion during surgery. The same volume of isotonic salinewas administered to the control group. Surgical time, heartrate and mean arterial blood pressure was measured.Results: In the magnesium group there was reduction insurgical time (103.54 mins vs 117.34 mins), although theanaesthestic time was 9 minutes longer in the Magnesiumgroup denoting a longer emergence time. The mean arterialpressure and heart rate were significantly reduced inMagnesium group(p<0.005). Postoperative shivering was alsoless in Magnesium group.Conclusion: Magnesium infusion resulted in a steady andsmooth reduction in mean blood pressure and reduced heartrate, with no episodes of severe hypotension. Furthermoremagnesium causes reduction in duration of surgical time andpostoperative shiveringMagnesium SulphateHypotensive AnaesthesiaLumbar SpineHeart RateMean Arterial Blood PressureShiveringEmergence TimeJournal ArticleIndiaPost Graduate Student, Department of Anaesthesiology, MGM Medical College, IndoreProfessor and HOD, Department of Anaesthesiology, MGM Medical College, IndoreAssociate Professor, Department of Anaesthesiology, MGM Medical College, Indore, India