Kumari, RashmiThappa, Devinder Mohan2013-07-242013-07-242013-05Kumari Rashmi, Thappa Devinder Mohan. Role of insulin resistance and diet in acne. Indian Journal of Dermatology, Venereology and Leprology. 2013 May-Jun; 79(3): 291-299.http://imsear.searo.who.int/handle/123456789/147464There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.enAcne pathogenesisdietinsulin like growth factor 1insulin resistanceAcne Vulgaris --diet therapyAcne Vulgaris --metabolismHumansHyperglycemia --drug therapyHyperglycemia --metabolismInsulin Resistance --physiologyLipogenesis --physiologyArticle