Devi, R. LakshmiSelvi, K. Josephine PudumaiMasoodu, K. Sathik MohamedDhineshkumar, P.Manigandan, R.2020-01-022020-01-022019-03Devi R. Lakshmi, Selvi K. Josephine Pudumai, Masoodu K. Sathik Mohamed, Dhineshkumar P., Manigandan R.. A Prospective Study of Thyrotoxicosis Clinical Presentation and Etiopathogenesis. Annals of International medical and Dental Research. 2019 Mar; 5(2): 13-152395-28222395-2814http://imsear.searo.who.int/handle/123456789/188811Thyrotoxicosis denotes the clinical syndrome that results from tissue exposure to excess circulating free thyroid hormones e thyroxine (3,5,30 ,50 -tetraiodo-L-thyronine; T4) and/or triiodothyronine (3,5,30 -triiodo-L-thyronine; T3). Aim: To study the clinical presentation and etiopathogenesis of thyrotoxicosis. Methods: Thyroid profile, x-ray neck and ECG were taken for the cases. Radio-Isotope study was not done since facilities are not available in our hospital. Surgery was the modality of treatment offered to all patients. Results: Most of the patients who were diagnosed to have thyrotoxicosis were in the age group 31-45 years. The incidence of thyrotoxicosis in females was high and the male. All the patients had a goiter. The most significant clinical features were palpitation, weight loss, diarrhea, sleep disturbances, excitability and heat intolerances in the order of frequency. Conclusion: From the evidence it is clear that after adequate control of toxicity with anti-thyroid drugs, surgery is the modality of treatment that can be safely offered to patients with thyrotoxicosis.thyrotoxicosishyperthyroidismGraves’ diseaseJournal ArticleIndiaAssistant Professor, Department of General Surgery, Tirunelveli Medical College, Tamilnadu.Associate Professor, Department of General Surgery, Tirunelveli Medical College, Tamilnadu.Postgraduate student, Department of General Surgery, Tirunelveli Medical College, Tamilnadu.