Kowli, Mugdha S.Chakrabarti, NilayBhadre, RohiniIndap, Shalaka2019-11-252019-11-252019-07Kowli Mugdha S., Chakrabarti Nilay, Bhadre Rohini, Indap Shalaka. Role Of Oral Pyridoxine (vitamin B6) Supplementation In The Reduction Of Hyperoxaluria And Prevention Of Recurrent Urolithiasis. Indian Journal of Applied Research. 2019 Jul; 9(7): 9-102249-555Xhttp://imsear.searo.who.int/handle/123456789/185135Our prospective, randomised controlled study was to assess the role of oral pyridoxine (Vitamin B6) supplementation in addition to standard dietary advice, compared against only dietary advice, in the reduction of urinary oxalate levels in patients with urinary calculi along with proven hyperoxaluria. 74 subjects were randomly divided into Interventional Group (n=38) who received oral Pyridoxine 40mg/day with dietary oxalate restriction and Control Group (n=36) who received only dietary oxalate restriction. Both groups were evaluated and statistically compared at the end of 3 months. Interventional group showed statistically significant (p = 0.0001) reduction in 24 hours urinary oxalate levels. Pyridoxine, cofactor in the alanine–glyoxalate–transaminase pathway converts glyoxalate to glycine and reduces oxalate production thereby decreasing hyperoxaluria, risk factor of urolithiasis. Oral Pyridoxine supplementation (40 mg/day) with dietary oxalate restriction can be a prophylactic measure for prevention of recurrence of calcium oxalate urolithiasis.Hyperoxaluriapyridoxine Supplementationprevention Of Recurrent UrolithiasisJournal ArticleIndiaFormer DNB Resident, Department of Surgery, K.J. Somaiya Medical College, Somaiya Ayurvihar, Sion, Mumbai, Maharashtra, India. Pincode – 400022Professor, Department of Surgery, K.J. Somaiya Medical College, Somaiya Ayurvihar, Sion, Mumbai, Maharashtra, India. Pincode – 400022Professor, Department of Biochemistry, K.J. Somaiya Medical College, Somaiya Ayurvihar, Sion, Mumbai, Maharashtra, India. Pincode – 400022Associate Professor, Department of Surgery, K.J. Somaiya Medical College, Somaiya Ayurvihar, Sion, Mumbai, Maharashtra, India. Pincode – 400022