Subhalakshmi, VJaiswal, RPriyadharshini, IKAmbika, M2025-08-132025-08-132025-03Subhalakshmi V, Jaiswal R, Priyadharshini IK, Ambika M. Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.. Online Journal of Health and Allied Sciences. 2025 Mar; 24(93): 1-50972-5997https://imsear.searo.who.int/handle/123456789/252876Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another major factor is apoptosis which is programmed cell death. Apoptosis generally happens in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event. There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression. This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.BCL2ImmunohistochemistryApoptosisCaspasesJournal ArticleIndiaResearch Associate, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), SalemProfessor and Head, Department of Oral and Maxillofacial Pathology and Microbiology, Sardar Patel Postgraduate Institute of Medical and Dental Sciences, LucknowAssociate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), SalemAssociate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), Salem