Padmanaban, G2015-07-292015-07-291993-03Padmanaban G. Specificity in the regulation of eukaryotic gene transcription. Journal of Biosciences. 1993 Mar; 18(1): 27-36.http://imsear.searo.who.int/handle/123456789/160847The regulation of eukaryotic gene transcription poses major challenges in terms of the innumerable protein factors required to ensure tissue or cell-type specificity. While this specificity is sought to be explained by the interaction of cis-acting DNA elements and the trans-acting protein factor(s), considerable amount of degeneracy has been observed in this interaction. Immunoglobulin heavy chain gene expression in Β cells and liver-specific gene expression are discussed as examples of this complexity in this article. Heterodimerization and post-translational modification of transcription factors and the organization of composite promoter elements are strategies by which diverse sets of genes can be regulated in a specific manner using a finite number of protein factors.enTranscription in eukaryotesregulationArticle