Thakur, C PSinha, G PSharma, VBarat, D1993-11-012009-06-031993-11-012009-06-031993-11-01Thakur CP, Sinha GP, Sharma V, Barat D. The treatment of kala-azar during pregnancy. National Medical Journal of India. 1993 Nov-Dec; 6(6): 263-5http://imsear.searo.who.int/handle/123456789/119737BACKGROUND. Kala-azar in pregnant women is difficult to treat because for them the two commonly used drugs, sodium stibogluconate and pentamidine, are not considered safe. We assessed the effect of amphotericin B on pregnancy, on the foetus and kala-azar. METHODS. Five pregnant women were administered amphotericin B at a dose of 1 mg/kg body weight daily starting with 0.5 mg/kg body weight till a total dose of 20 mg/kg body weight was given. The progress of pregnancy was monitored ultrasonographically and the mothers and children were followed for six months. RESULTS. All the 5 women were cured of the disease and there was no harmful effect on the children. CONCLUSION. Amphotericin B cures kala-azar during pregnancy with no harmful effects on the foetus.engAdultAmphotericin B --therapeutic useFemaleHumansLeishmaniasis, Visceral --drug therapyPregnancyPregnancy Complications, Parasitic --drug therapyCase Reports