Kandarkar, S VSirsat, S M2009-05-282009-05-281990-01-01Kandarkar SV, Sirsat SM. Periodic histopathological and ultrastructural changes of excess vitamin A on oral carcinogenesis. Indian Journal of Experimental Biology. 1990 Jan; 28(1): 10-7http://imsear.searo.who.int/handle/123456789/59667In this study initially a precancerous condition, leukoplakia, was develop at 6 weeks treatment of DMBA whereas in the animals treated both DMBA + Vit. A, leukoplakia was seen at 10 weeks followed by papilloma or nodules at 12 weeks. Tumours induced by DMBA were more in number than DMBA + Vit. A treated tumours. The histological and ultrastructural changes were enhanced and prominent in DMBA treated animals at 12 weeks, where as these changes were considerably less in animals treated with DMBA + vit. A at 12 weeks.eng9,10-Dimethyl-1,2-benzanthracene --toxicityAnimalsCricetinaeFemaleLeukoplakia, Oral --chemically inducedMaleMesocricetusMicroscopy, ElectronMouth Neoplasms --chemically inducedPapilloma --chemically inducedVitamin A --pharmacologyJournal Article