Komath, ManojVarma, H K2009-05-282009-05-282004-07-27Komath M, Varma HK. Fully injectable calcium phosphate cement--a promise to dentistry. Indian Journal of Dental Research. 2004 Jul-Sep; 15(3): 89-95http://imsear.searo.who.int/handle/123456789/51812Calcium phosphate cements (CPC) are self setting and biocompatible bone substitute materials with potential applications in dentistry. However, its clinical use has been challenged by poor rheological properties. A novel formulation of CPC has been developed, which gives a fully injectable and cohesive paste. This work investigates the suitability of the new "fully injectable calcium phosphate cement" (FI-CPC) for dental applications. The cementing properties, material characteristics, and the rheological properties were tested using a battery of material characteristics methods. The biocompatibility was also evaluated as per ISO 7405. The setting time (20 min) and compressive strength (>11 Mpa) of FI-CPC satisfy the clinical requirements. It underwent setting without any exothermic reaction, keeping good dimensional stability. The cement paste could be extruded through a 18-gauge needle, easily and fully. It showed excellent cohesion when immersed in water. FI-CPC was seen to set into a micro-porous mass of hydroxyapatite, the mineral part of human dentin. It showed good attachment to dentin walls, when filled in tooth perforations. FI-CPC was found non-toxic, non-allergic, non-pyrogenic, and soft-tissue compatible. The study shows that FI-CPC provides a self setting bio-compatible paste with excellent rheological properties for surgical applications. The set cement provides good and stable sealing. The osteoconductive property is an added advantage. FI-CPC proves to be an ideal material for endodontic sealing/filling and periodontic repair.engAnimalsBiocompatible Materials --chemistryBone Substitutes --chemistryCalcium Phosphates --chemistryCells, CulturedChemistry, PharmaceuticalCompressive StrengthDental Materials --chemistryDurapatite --chemistryElectron Probe MicroanalysisFibroblasts --drug effectsHumansMaterials TestingMiceMuscle, Skeletal --drug effectsRheologySkin --drug effectsSpectroscopy, Fourier Transform InfraredSurface PropertiesTime FactorsJournal Article