Kaul, UpendraSethi, RishiRoy, SanjeebGoel, P.K.Chouhan, Nagendra SinghVijayvergiya, RajeshNarang, ManishPriyadarshiniBaruah, D.K.Mathew, Rony2025-05-092025-05-092024-12Kaul Upendra, Sethi Rishi, Roy Sanjeeb, Goel P.K., Chouhan Nagendra Singh, Vijayvergiya Rajesh, Narang Manish, Priyadarshini, Baruah D.K., Mathew Rony . Morphological characterization of coronary plaques in young indian patients with acute coronary syndrome: A multicentric study. Indian Heart Journal. 2024 Dec; 76(6): 370-3750019-4832https://imsear.searo.who.int/handle/123456789/242749Objectives: The prevalence of atherosclerosis and acute coronary syndrome (ACS) is increasing in young Indians (1850 years of age). However, the characteristics of atherosclerotic plaques in such individuals are poorly understood, presenting distinct challenges for the management of ACS. This study aims to analyze plaque characteristics in young Indian patients with ACS who underwent percutaneous coronary intervention (PCI) using optical coherence tomography (OCT) imaging. Methods: This was a prospective, multicentric, non-interventional study on patients aged 1850 years presenting with ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction, or unstable angina, and were scheduled to undergo OCT-guided PCI. Major adverse cardiac events (MACE) were assessed post- procedure and at the 6-month and 12-month follow-ups. Results: The study included 100 ACS patients (mean age = 43.6 5.2 years), with 51% presenting with STEMI. Pre-PCI OCT assessment showed that fibrous plaques (75%) were most common followed by plaques containing macrophages (27%), microchannels (20%), and calcified nodules (14%). In addition, plaque rupture, plaque erosion, and lipid-rich plaques, along with red, white, and mixed thrombi, were observed in 31%, 25%, 24%, 21%, 14%, and 17% (total thrombus occurrence = 52%) of the patients, respectively. At 12 months, the MACE (coronary artery bypass graft) rate was 1%. Conclusions: Young Indian patients with ACS displayed a range of plaque morphologies identified through pre- PCI OCT. Among these, fibrous plaques were the most prominent type, followed by plaques containing macro- phages. Additionally, plaque rupture, plaque erosion, and lipid-rich plaques were also observed in this population.Acute coronary syndromeMorphologyOptical coherence tomographyPlaque ruptureYoung patientsJournal ArticleIndiaBatra Hospital & Medical Research Centre, New Delhi, IndiaKing Georges Medical University, Lucknow, IndiaFortis Hospital, Jaipur, IndiaSanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IndiaMedantaThe Medicity, Gurgaon, IndiaPost Graduate Institute of Medical Education & Research, Chandigarh, IndiaAbbott Vascular, Abbott Healthcare Pvt Ltd, New Delhi, IndiaBatra Hospital & Medical Research Centre, New Delhi, IndiaApollo Hospital, Visakhapatnam, IndiaLisie Hospital, Ernakulam, India