Tiwari, SanchitAlam, RoshanAhmad, IsrarSingh, SeemaSonkar, Satyendra KumarGyanendra, Kumar SonkarMohammad, Kaleem Ahmad2020-09-242020-09-242019-06Tiwari Sanchit, Alam Roshan, Ahmad Israr, Singh Seema, Sonkar Satyendra Kumar, Gyanendra Kumar Sonkar, Mohammad Kaleem Ahmad. Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Jun; 8(3): 1-62282-02382393-932Xhttp://imsear.searo.who.int/handle/123456789/203818Diabetic nephropathy (DN) is a chronic complication of both type 1 and type 2 diabetes. However, there is still inadequate understanding of the exact mechanism related to progressive diabetic renal disease. The GLUT-1 XbaI gene polymorphism in the glucose transporter has been suggested in the development of DN. However, its association with T2DM and DN is controversial and has not been established in different ethnic populations. To enhance the understanding of GLUT-1 XbaI gene polymorphism in the context of T2DM and DN. We investigated the possible genetic association of GLUT-1 XbaI polymorphism with T2DM and DN in North Indian population. 100 T2DM patients and 100 patients of DN with 100 healthy controls were included in the study. GLUT-1 XbaI polymorphism was determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism). The obtained data showed no significant association between GLUT-1 XbaI gene polymorphism with T2DM and DN leading us to conclude that GLUT-1 XbaI gene polymorphism may not have major effects on T2DM and DN in North Indian population.Diabetic nephropathyGene polymorphismGlucose transporter geneRestriction fragment length polymorphismType 2 Diabetes melitusJournal ArticleIndiaDepartment of Biochemistry, King George’s Medical University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Science& Research, Lucknow, IndiaDepartment of Biochemistry, King George’s Medical University, Lucknow, IndiaDepartment of Biochemistry, King George’s Medical University, LucknowDepartment of Medicine, King George’s Medical University, LucknowDepartment of Biochemistry, King George’s Medical University, Lucknow, IndiaDepartment of Biochemistry, King George’s Medical University, Lucknow, India