Khadilkar, Urmila NRao, A T KSahoo, Kausalya KumariPai, Mukta R2008-03-012009-05-302008-03-012009-05-302008-03-01Khadilkar UN, Rao AT, Sahoo KK, Pai MR. Langerhans cell histiocytosis of mediastinal node. Indian Journal of Pediatrics. 2008 Mar; 75(3): 294-6http://imsear.searo.who.int/handle/123456789/82330The predominant clinical and radiological features of Langerhans Cell Histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation. In the present study, LCH was presumptively diagnosed on Ultrasound guided Fine needle aspiration cytology (FNAC) of the mediastinal lymph node in a 18 month-old child. The diagnosis was confirmed by histological examination of the biopsy material.S-100 protein localization in the LCH cells is often positive on immunohistochemistry.engBiopsy, NeedleDiagnosis, DifferentialHistiocytosis, Langerhans-Cell --diagnosisHumansInfantLymph Nodes --pathologyMaleMediastinum --pathologyCase Reports