Baruah, ChitralekhaDeb, BikramadityaKutum, NiharikaDutta, Daisy2020-09-242020-09-242019-11Baruah Chitralekha, Deb Bikramaditya, Kutum Niharika, Dutta Daisy. A Clinical Study on NPSLE in a Tertiary Care Hospital in Northeast India. International Journal of Medical Research Professionals. 2019 Nov; 5(6): 30-342454-63642454-6356http://imsear.searo.who.int/handle/123456789/203480Introduction: Neuropsychiatric Systemic LupusErythematosus (NPSLE) is a disease with central andperipheral nervous system manifestations. The diagnosis ofNPSLE is often a diagnostic challenge though the criteria forNPSLE is well-established.Objective: To study the prevalence and pattern ofneuropsychiatric manifestations in SLE.Materials and Methods: This hospital based observationalstudy was carried out from Nov 2017 to June 2018. A total of58 cases of SLE were assessed clinically and investigatedaccordingly. Special emphasis was given to look forNeurological involvement. MMSE, HAM A and HAM D scaleswere used for assessment of cognitive dysfunction, anxiety anddepression respectively. The disease activity was measured bythe SLEDAI.Results: In a total of 58 patients with SLE evaluated, 92%were female. The most common age group was 21 to 30 years.Mean age was 25.6 years. Nervous system involvement wasfound in 37 (63.79%) patients. Headache was the mostfrequent manifestation, present in 32 (55.17%) patientsfollowed by Cognitive dysfunction in 8 patients (13.79%).Seizure disorder was present in 6 (10.34%), acute confusionalstate in 2 (3.44%), depression in 4 (6.89%), anxiety in 2(3.44%) and psychosis in 2 (26.31%) patients. Asepticmeningitis and peripheral neuropathy was found in 2 (3.44%)and 1 (1.72%) patients respectively. Many of the patients hadmore than one neurological involvement. SLEDAI score washigh in SLE patients with neurological manifestations.Conclusion: The frequency of Neuropsychiatric involvementwas found in the majority of the patients with SLE andheadache was the most common manifestation. Patients withNPSLE showed high disease activity.SLENPSLESLEDAI.Journal ArticleIndiaProfessor, Department of Medicine, Gauhati Medical College and Hospital, Guwahati, Assam, IndiaPost Graduate Trainee, Department of Medicine, Gauhati Medical College and Hospital, Guwahati, Assam, India