Mamta, V ManglaniYashwant, R GabhaleLala, Mamatha MSekhar, RohiniMore, Dipti2020-04-232020-04-232018-02Mamta V Manglani , Yashwant R Gabhale , Lala Mamatha M , Sekhar Rohini , More Dipti. HLA- B*5701 Allele in HIV-infected Indian Children and its Association with Abacavir Hypersensitivit. Indian Pediatrics. 2018 Feb; 55(2): 140-1420974-75590019-6061http://imsear.searo.who.int/handle/123456789/199023Objective: To determine the prevalence of HLA-B*5701 allele in HIV-infected children, andtofind its associationwith Abacavir hypersensitivity. Methods: Children (2 to 18 y) already on,or to be initiated on Abacavir were included for PCR sequencing to detect HLA-B*5701.Outcome measures were: proportion with HLA B*5701 allele and hypersensitivity withAbacavir. Abacavir was stopped if patient tested positive for HLA-B*5701 allele. Results:100 children(median age 11 y) were enrolled; 10 were already on Abacavir. HLA-B*5701positivity was observed in 11 (11%) children. Two of these 11 children developedhypersensitivity after initiation of Abacavir. Abacavir was thereafter stopped in all whotested HLA-B*5701 positive, irrespective of the development of hypersensitivity reaction.Conclusion: HLA-B*5701 allele was present in 11 (11%) of HIV-infected children,of whichtwo developed Abacavir hypersensitivity. None of the patients without the allele developedhypersensitivity.Antiretroviral drugsAdverse effectsGeneticsHIVTreatmentJournal ArticleIndiaPediatric Centre of Excellence for HIV Care (PCoE), Department of Pediatrics, Lokmanya Tilak Municipal Medical Collegeand General Hospital, Sion, Mumbai, India.