Reddy, ADParija, AMadhavi, BMadhav, SVShalini, BSreenivasulu, MVenkatswami, PReddy, TRKGopal, SH.2025-05-122025-05-122024-08Reddy AD, Parija A, Madhavi B, Madhav SV, Shalini B, Sreenivasulu M, Venkatswami P, Reddy TRK, Gopal SH.. Saccharomyces boulardii: An Efficient Yeast Probiotic for Pediatric Gut Dysbiosis Management. International Journal of Scientific Study. 2024 Aug; 12(5): 17-272321-63792321-595Xhttps://imsear.searo.who.int/handle/123456789/246967The human microbiome, comprising diverse microorganisms across body surfaces, profoundly influences host physiology, metabolism, and nutrition. Dysbiosis, an imbalance within gut microbiota, triggers health issues such as inflammation, autoimmune disorders, and obesity. Probiotics, which are live microorganisms known for their health benefits, when used correctly, hold promise for managing dysbiosis. Prebiotics, probiotics, synbiotics, and immunobiotics have demonstrated efficacy in addressing gut dysbiosis. Among these supplements, yeast-based probiotics such as Saccharomyces boulardii CNCM I-745 demonstrate significant benefits over bacterial alternatives. Yeast cells, being larger and more resistant to digestive enzymes and bile than bacterial cells, serve as a barrier against pathogens and possess immunomodulatory properties, enhancing gut health. S. boulardii CNCM I-745, with its unique features such as pathogen binding, immune stimulation, and toxin neutralization without genetic transfer, notably mitigates antibiotic resistance risk. It effectively prevents antibiotic-associated diarrhea and pediatric acute gastroenteritis compared to bacterial probiotics, endorsed by the international guidelines for managing acute diarrhea safely. In addition, oral probiotics may aid microbiota restoration and potentially prevent other diseases.DysbiosisGut healthMicrobiomeProbioticsSaccharomyces boulardii CNCM I-745Journal ArticleIndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, IndiaDheeraj Hospital, Proddatur, Andhra Pradesh, India, Sai Sudha Clinic, Cuttack, Odisha, India, Mathrutva Children’s and Speciality Clinic, Tirupati, Andhra Pradesh, India, Om Clinic, Hanamkonda, Telangana, India, Shalini Childrens Clinic, Hyderabad, Telangana, India, Hrudaya Hospital, Anantapur, Andhra Pradesh, India, PVS Hospital, Nellore, Andhra Pradesh, India, Department of General Surgeon, Sri Sai Suraksha Children’s Hospital, Kurnool, Andhra Pradesh, India, Dr. S Harigopal Clinic, Rajampet, Andhra Pradesh, India