Boseh, ArunabhaDalal, Sorab N2020-11-182020-11-182019-06Boseh Arunabha, Dalal Sorab N. 14-3-3 proteins mediate the localization of Centrin2 to centrosome. Journal of Biosciences. 2019 Jun; 44(2): 1-100250-59910973-7138http://imsear.searo.who.int/handle/123456789/21438214-3-3e and 14-3-3c localize to the centrosome and regulate centrosome duplication, by inhibiting cdc25C function. As14-3-3c and 14-3-3e form a complex with centrosomal proteins, we asked if this ability was required to regulate centrosomeduplication. The results in this report demonstrate that 14-3-3e and 14-3-3c form a complex with Centrin2 and that thebinding site is located in the N-terminal EF hand in Centrin2, EF1. A Centrin2 mutant that does not form a complex with14-3-3 proteins displays a punctate cytoplasmic localization and does not localize to the centrosome. These results suggestthat in addition to negatively regulating centrosome duplication as previously reported, 14-3-3 proteins might also berequired for centriole biogenesis by regulating the localization of Centrin2 at the centrosome.CentrosomecentrioleCentrin214-3-3Journal ArticleIndiaKS230, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai 410210, India Homi Bhabha National Institute, Training School complex, Anushakti Nagar, Mumbai 400085, IndiaKS230, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai 410210, India Homi Bhabha National Institute, Training School complex, Anushakti Nagar, Mumbai 400085, India