Mathrubootham, SridharShriraam, MahadevanLatha, VishwanathanAnbezhil, Subbarayan2020-04-232020-04-232018-03Mathrubootham Sridhar, Shriraam Mahadevan, Latha Vishwanathan, Anbezhil Subbarayan. Subclinical Hypothyroidism: A Prospective Observational Study from Southern India. Indian Pediatrics. 2018 Mar; 55(3): 219-2210974-75590019-6061http://imsear.searo.who.int/handle/123456789/199042Objective: To assess the natural history and progression of subclinical hypothyroidism and tostudy factors which help predict evolution of subclinical hypothyroidism into overthypothyroidism. Methods: Longitudinal study in 40 children (2-16 yrs) presenting withsubclinical hypothyroidism in a tertiary care unit in Chennai, India. Patients showing evidenceof overt hypothyroidism or thyroid stimulating hormone ?15 mIU/mL during follow-up werestarted on thyroxine. Others were followed up with 3-monthly thyroid function tests up to oneyear. Results: At the end of our study period 3 (7.5%) were overtly hypothyroid, 16 (40%)remained as subclinical hypothyroid, and 21 (52.5%) became euthyroid. Evidence of autoimmunity at baseline was a significant (P<0.05) risk factor for progression to overthypothyroidism. Conclusions: Subclinical hypothyroidism in children, with thyroidstimulating hormone upto 15 mIU/L and irrespective of thyroid autoimmunity, needs onlyperiodic clinical and biochemical follow up. Thyroid autoimmunity may point to an increasedprobability of progression to overt hypothyroidism.AutoimmunityEuthyroidOutcomeTPO antibodyJournal ArticleIndiaDepartments of Pediatrics Apollo Children’s Hospital, Chennai, Tamil Nadu, IndiaPediatric Endocrinology, Apollo Children’s Hospital, Chennai, Tamil Nadu, India