Giangrande, P L F2003-08-272009-05-302003-08-272009-05-302003-08-27Giangrande PL. Treatment of patients with haemophilia and inhibitory antibodies. Indian Journal of Pediatrics. 2003 Aug; 70(8): 655-9http://imsear.searo.who.int/handle/123456789/7951226 references.The development of inhibitory antibodies is a complication which arise in approximately 10% of patients with haemophilia A. The underlying genetic mutation is the single most important predisposing cause, although other risk factors have been identified. Periodic screening for inhibitors is a vital aspect of haemophilia care. The consequences of inhibitor development are very significant in terms of morbidity and cost. Several agents are now available for control of bleeding, but these are often very expensive. The most useful agents include recombinant activated factor VII, prothrombin complex concentrates and porcine factor VIII. It is possible to suppress antibody production with immune tolerance, which is successful in approximately 85% of cases and relapse is rare.engBlood Coagulation Factor Inhibitors --bloodBlood Coagulation Factors --therapeutic useChildChild, PreschoolFactor VIII --therapeutic useFactor VIIa --therapeutic useGenetic Predisposition to DiseaseHemophilia A --bloodHumansImmune Tolerance --drug effectsInfantJournal Article