Emmanuel, SAmalraj, TIgnacimuthu, S2009-05-282009-05-282001-12-23Emmanuel S, Amalraj T, Ignacimuthu S. Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage. Indian Journal of Experimental Biology. 2001 Dec; 39(12): 1305-7http://imsear.searo.who.int/handle/123456789/59049Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Results of this study revealed that coumestans of W. calendulacea afforded a significant protective action in the alleviation of paracetamol induced hepatocellular injury.engAcetaminophen --toxicityAcid Phosphatase --metabolismAlanine Transaminase --metabolismAnimalsAspartate Aminotransferases --metabolismAsteraceae --chemistryChromatography, Thin LayerL-Lactate Dehydrogenase --metabolismLiver --drug effectsPlant Extracts --pharmacologyPlant Leaves --chemistryRatsRats, WistarJournal Article