Wu, XiangmeiDuan, Lijiang2025-08-132025-08-132025-06Wu Xiangmei, Duan Lijiang . Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 300-3040377-49290974-5130https://imsear.searo.who.int/handle/123456789/253969Background: Investigation of a potential prognostic marker expressed innon?small cell lung cancer (NSCLC) can help patients benefit from newtarget therapeuticmodalities. Aims: To study the expression and correlationof P53 protein and epithelial–mesenchymal transition (EMT) relatedmakers in NSCLC. Materials and Methods: 32 cases were selected forimmunohistochemistry analysis to evaluate the expression of P53 andEMT?related makers. Results: The positive expression rate of P53 and theincidence of EMT in NSCLC were closely linked to TNM stages, differentiationdegree, and lymph node metastasis (P < 0.05). A positive association was foundbetween P53 and EMT (r = 0.380, P < 0.05). Conclusions: There is a positiveassociation between P53, snail, and EMT. P53 may affect EMT in NSCLC byup?regulating the expression of Snail and further promoting cancer invasionand metastasis.Epithelial–mesenchymal transitionimmunohistochemistrynon?small cell lung cancerP53Journal ArticleIndiaDepartment of Pathology, Beijing Geriatric Hospital, Beijing, ChinaDepartment of Pathology, Beijing Geriatric Hospital, Beijing, China