Biswas, K DPurohit, Deepak2023-06-172023-06-172022-11Biswas K D, Purohit Deepak. Role of PPI and importance of anti-reflux agents in the treatment of NERD. Journal of The Indian Medical Association. 2022 Nov; 120(11): 69-700019-5847http://imsear.searo.who.int/handle/123456789/216635Background: Esomeprazole, an S-isomer of omeprazole, is a much more potent acid inhibitor than most other currently available PPIs and gives excellent results. Therefore, it is a first-line drug for acid-related diseases like NonErosive Reflux Disease (NERD). Yet, patients demand faster onset and response. Aim : To establish the role of esomeprazole and the importance of anti-reflux agents like a combination of two antacids (calcium carbonate and sodium bicarbonate) and alginate in treating NERD. Conclusion: Esomeprazole therapy shows potential efficacy in the continuous maintenance treatment of the NERD. However, it is suggested that to improve the efficiency of esomeprazole for the treatment of NERD; we can supplement the drug with antacids (sodium bicarbonate and calcium carbonate) and alginates.EsomeprazolePPIAntacidsNon-erosive reflux diseaseAlginatesJournal ArticleIndiaMD, DM (Gastro), Head of the Department of Medical Gastroenterology, Medical College, Kolkata 700073MD, DM (Gastro) PDT, Medical College, Kolkata 700073