Baral, RChakraborty, AMaity, P2009-05-282009-05-281993-10-01Baral R, Chakraborty A, Maity P. Alterations in large gut associated lymphatic tissues (LGALT) during experimental colorectal carcinogenesis. Indian Journal of Experimental Biology. 1993 Oct; 31(10): 793-6http://imsear.searo.who.int/handle/123456789/61794Alterations in large gut associated lymphatic tissues (LGALT) were studied histologically during 20-methylcholanthrene (MCA) induced colorectal carcinogenesis. Precancerous changes in LGALT included hyperplasia, hyperchromasia of lymphocytes and enlargement of lymphoid follicles. In addition, follicular invasion in muscular layer and cellular disorganization of diffuse lymphatic tissues were observed in neoplasia. Since, LGALT showed remarkable changes during carcinogenesis, this aspect may be considered during assessment of preneoplastic lesions, along with other histologic features of early neoplasia.engAnimalsColorectal Neoplasms --chemically inducedIntestine, Large --pathologyLymphoid Tissue --pathologyMaleMethylcholanthrene --toxicityPrecancerous Conditions --pathologyRatsRats, Sprague-DawleyJournal Article