Prechapanich, JaparathChoavaratana, RoungsinLaokirkkiat, PitakPetyim, SomsinMakemaharn, Orawan2012-02-062012-02-062008-11Prechapanich Japarath, Choavaratana Roungsin, Laokirkkiat Pitak, Petyim Somsin, Makemaharn Orawan. Preliminary data of preimplantation genetic diagnosis for aneuploidy screening using fluorescent in situ hybridization in Siriraj Hospital. Siriraj Medical Journal, 2008 Nov; 60(6): 344-348.http://imsear.searo.who.int/handle/123456789/136738Objective: Preimplantation genetic diagnosis (PGD) is technique for detecting genetic diseases. Preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) using fluorescent in situ hybridization (FISH) has been used worldwide including at Siriraj Hospital. The objective of this study was to comparethe pregnancy rate between a PGD-AS group with standard assisted reproductive techniques (ARTs) in Siriraj Hospital. Methods: Couples who requested PGD-AS underwent a standard ARTs process followed with blastomere biopsy for FISH analysis. The pregnancy rate was compared among the PGD-AS group and the control group. The control group was divided into 2 subgroups – all patients required ARTs subgroup and age ≥ 35 yrs. subgroup. Results: 6 stimulated cycles from 4 patients were performed in the PGD-AS group. The pregnancy rate per stimulated cycle in the PGD-AS group, control group and age ≥ 35 yrs group were 33.33%, 16.20% and 12.05% respectively. Moreover, the pregnancy rate per transferred cycles in the PGD-AS group, control group and age ≥ 35 yrs group were 40.00%, 21.02% and 13.17% respectively. Conclusion: PGD is an advanced method for detecting genetic defects. PGA-AS might increase the pregnancy rate.enPreimplantation genetic diagnosis (PGD)preimplantaion genetic diagnosis for aneuploidy screening (PGD-AS)fluorescent in situ hybridization (FISH)Article