Tharakan, Sheeja TKuttan, GirijaKuttan, RamadasanKesavan, MAustin,Rajagopalan, K2009-05-282009-05-282008-01-14Tharakan ST, Kuttan G, Kuttan R, Kesavan M, Austin , Rajagopalan K. Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV. Indian Journal of Experimental Biology. 2008 Jan; 46(1): 47-51http://imsear.searo.who.int/handle/123456789/60766Immunostimulatory activity of AC II, a registered ayurvedic preparation prepared at Amala Ayurvedic Research Centre for treating HIV and AIDS is reported. AC II administration could significantly enhance the mitogen-induced proliferation of lymphocytes of spleen cells. It was also found to increase cell-mediated immune responses in normal and tumor-bearing control animals. Oral administration of AC II significantly enhanced Natural Killer cell activity in normal and tumor-bearing animals on the 7th day, which was observed earlier than the tumor-bearing control animals and normal animals. Antibody dependent cellular cytotoxicity (ADCC) was also increased in AC II treated normal and tumor-bearing animals. An early enhancement of antibody-dependent complement-mediated cytotoxicity was also observed by the administration of AC II in normal as well as tumor-bearing animals. Treatment with AC II elevated the levels of IL-2, TNF-alpha and IFN-gamma in normal mice. Administration of AC II was also found to increase the cytotoxic T lymphocyte production in EL4 treated mice. These studies support the use of this immune stimulatory preparation in HIV patients.engAnimalsAnti-HIV Agents --therapeutic useCell ProliferationHIV Infections --drug therapyHumansInterferon-gamma --metabolismInterleukin-2 --metabolismK562 CellsKiller Cells, Natural --cytologyMAP Kinase Signaling SystemMedicine, AyurvedicMiceMice, Inbred BALB CSpleen --metabolismTumor Necrosis Factor-alpha --metabolismJournal Article